abstract：BACKGROUND & AIMS:Electroneutral NaCl absorption across small intestine contributes importantly to systemic fluid balance. Disturbances in this process occur in both obstructive and diarrheal diseases, eg, cystic fibrosis, secretory diarrhea. NaCl absorption involves coupling of Cl(-)/HCO(3)(-) exchanger(s) primarily w...

journal_title：Gastroenterology

authors： Walker NM,Simpson JE,Yen PF,Gill RK,Rigsby EV,Brazill JM,Dudeja PK,Schweinfest CW,Clarke LL

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND & AIMS:Weight loss in response to sibutramine is highly variable. We assessed the association of specific markers of polymorphisms of candidate alpha2A adrenoreceptor, 5-HT transporter, and GNbeta3 genes and weight loss with sibutramine. METHODS:We conducted a randomized, double-blind, pharmacogenetic study...

journal_title：Gastroenterology

authors： Grudell AB,Sweetser S,Camilleri M,Eckert DJ,Vazquez-Roque MI,Carlson PJ,Burton DD,Braddock AE,Clark MM,Graszer KM,Kalsy SA,Zinsmeister AR

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND & AIMS:Colorectal cancer screening with diagnostic imaging can detect polyps. The management of patients whose largest polyp is less than 10 mm is uncertain. The primary aim of this study was to determine rates of advanced histology in patients undergoing colorectal cancer screening whose largest polyp is 9 ...

journal_title：Gastroenterology

authors： Lieberman D,Moravec M,Holub J,Michaels L,Eisen G

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND & AIMS:Although a number of epidemiologic studies have found dietary fiber and whole grains to be inversely associated with colorectal cancer incidence, studies of dietary and other risk factors for small intestinal cancer have been sparse and all of a case-control design. We conducted a prospective cohort s...

journal_title：Gastroenterology

authors： Schatzkin A,Park Y,Leitzmann MF,Hollenbeck AR,Cross AJ

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND & AIMS:Genetic variation is invoked as a strong component underlying primary biliary cirrhosis (PBC) and other autoimmune disorders. Data suggest that some of this genetic risk is shared, affecting function of the immune mechanisms controlling self-tolerance. Cytotoxic T-lymphocyte antigen 4 (CTLA4) encodes ...

journal_title：Gastroenterology

authors： Juran BD,Atkinson EJ,Schlicht EM,Fridley BL,Lazaridis KN

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND & AIMS:Early growth response gene-1 (Egr-1) is an important inflammatory transcription factor. We hypothesize that leukocyte-derived Egr-1 plays a key inflammatory role in causing postoperative ileus. METHODS:Wild-type, Egr-1 knockout, and chimera mice (constructed by irradiation followed by injection with ...

journal_title：Gastroenterology

authors： Schmidt J,Stoffels B,Moore BA,Chanthaphavong RS,Mazie AR,Buchholz BM,Bauer AJ

更新日期：2008-09-01 00:00:00

abstract：:Both high-resolution manometry (HRM) and impedance-pH/manometry monitoring have established themselves as research tools and both are now emerging in the clinical arena. Solid-state HRM capable of simultaneously monitoring the entire pressure profile from the pharynx to the stomach along with pressure topography plott...

journal_title：Gastroenterology

authors： Kahrilas PJ,Sifrim D

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND & AIMS:Notch downstream targets are fundamental to intestinal cell lineage commitment and are suggested as therapeutic targets for colon cancer cells. However, the role of endogenous Notch signaling through receptor-ligand interaction, and effects of its longer term down-regulation on intestinal homeostasis,...

journal_title：Gastroenterology

authors： Guilmeau S,Flandez M,Bancroft L,Sellers RS,Tear B,Stanley P,Augenlicht LH

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND & AIMS:Numerous studies have linked the proliferation of liver progenitor cells (LPCs) during chronic liver disease to the risk for development of hepatocellular carcinoma. Thus, selective inhibition of LPC growth during preneoplastic injury may prevent or delay the onset of liver cancer. Rats carrying a ger...

journal_title：Gastroenterology

authors： Knight B,Tirnitz-Parker JE,Olynyk JK

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND & AIMS:Toll-like receptor (TLR)-dependent signaling was proposed as immunotherapeutic targets against invading pathogens and tumorigenesis. Here, we investigated whether TLR5-dependent signaling modulates colonic tumor development in mouse xenograft model of human colon cancer. METHODS:The expression of mye...

journal_title：Gastroenterology

authors： Rhee SH,Im E,Pothoulakis C

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND & AIMS:Congenital tufting enteropathy (CTE) is a rare autosomal recessive diarrheal disorder presenting in the neonatal period. CTE is characterized by intestinal epithelial cell dysplasia leading to severe malabsorption and significant morbidity and mortality. The pathogenesis and genetics of this disorder ...

journal_title：Gastroenterology

authors： Sivagnanam M,Mueller JL,Lee H,Chen Z,Nelson SF,Turner D,Zlotkin SH,Pencharz PB,Ngan BY,Libiger O,Schork NJ,Lavine JE,Taylor S,Newbury RO,Kolodner RD,Hoffman HM

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND & AIMS:This study attempts to elucidate a part of the genetic predisposition to the sporadic invasive ductal adenocarcinoma of the pancreas focusing on the genes implicated in the gene-environment interactions in carcinogenesis. METHODS:First, 227 single nucleotide polymorphisms (SNPs) of 46 genes were geno...

journal_title：Gastroenterology

authors： Ohnami S,Sato Y,Yoshimura K,Ohnami S,Sakamoto H,Aoki K,Ueno H,Ikeda M,Morizane C,Shimada K,Sakamoto Y,Esaki M,Saito I,Hirose H,Saito D,Sugimura H,Kosuge T,Okusaka T,Yoshida T

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND & AIMS:The US Medicare indications for intestinal transplantation are based on failure of home parenteral nutrition. The American Society of Transplantation also includes patients at high risk of death from their primary disease or with high morbidity intestinal failure. A 3-year prospective study evaluated ...

journal_title：Gastroenterology

authors： Pironi L,Forbes A,Joly F,Colomb V,Lyszkowska M,Van Gossum A,Baxter J,Thul P,Hébuterne X,Gambarara M,Gottrand F,Moreno Villares JM,Messing B,Goulet O,Staun M,Home Artificial Nutrition Working Group of the European Society fo

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND & AIMS:Diarrheal disease is a major cause of morbidity and mortality in infants and children worldwide. Evidence has indicated immature human enterocytes and their interaction with bacteria and enterotoxins may account for the noted increased susceptibility of neonates to diarrhea. Our aim was to characteriz...

journal_title：Gastroenterology

authors： Lu L,Bao Y,Khan A,Goldstein AM,Newburg DS,Quaroni A,Brown D,Walker WA

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND & AIMS:This study investigated whether obesity, diabetes, and other metabolic factors are independently associated with hepatocellular carcinoma (HCC), stratified by hepatitis B virus (HBV) and hepatitis C virus (HCV) serostatus, and explored the possible joint influence of obesity/diabetes and HBV/HCV infec...

journal_title：Gastroenterology

authors： Chen CL,Yang HI,Yang WS,Liu CJ,Chen PJ,You SL,Wang LY,Sun CA,Lu SN,Chen DS,Chen CJ

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND & AIMS:Although the cell of origin for pancreatic cancer remains unknown, prior studies have suggested that pancreatic neoplasia may be initiated in progenitor-like cells. To examine the effects of oncogene activation within the pancreatic progenitor pool, we devised a system for real-time visualization of b...

journal_title：Gastroenterology

authors： Park SW,Davison JM,Rhee J,Hruban RH,Maitra A,Leach SD

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND & AIMS:The finding of bone morphogenetic protein (BMP) receptor 1a mutations in juvenile polyposis suggests that BMPs are important in colorectal cancer (CRC). We investigated the BMP pathway in sporadic CRC. METHODS:We investigated BMP receptor (BMPR) expression using immunoblotting and sequenced BMPR2 in ...

journal_title：Gastroenterology

authors： Kodach LL,Wiercinska E,de Miranda NF,Bleuming SA,Musler AR,Peppelenbosch MP,Dekker E,van den Brink GR,van Noesel CJ,Morreau H,Hommes DW,Ten Dijke P,Offerhaus GJ,Hardwick JC

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic lipid retention (steatosis) predisposes hepatitis. We investigated the mechanisms of lymphocyte homing to fatty liver and the role of lipopolysaccharide (LPS) in the onset of inflammation in ob/ob mice. METHODS:We decreased intestinal bacterial compounds by oral antibiotic treatment to test t...

journal_title：Gastroenterology

authors： Bigorgne AE,Bouchet-Delbos L,Naveau S,Dagher I,Prévot S,Durand-Gasselin I,Couderc J,Valet P,Emilie D,Perlemuter G

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND & AIMS:Nuclear factor kappaB (NF-kappaB) is the master regulator of tumor necrosis factor (TNF) susceptibility. Although mitochondrial glutathione (mGSH) depletion was shown to sensitize hepatocytes to TNF despite NF-kappaB activation, the mechanisms involved, particularly the role of Bax oligomerization and...

journal_title：Gastroenterology

authors： Marí M,Colell A,Morales A,Caballero F,Moles A,Fernández A,Terrones O,Basañez G,Antonsson B,García-Ruiz C,Fernández-Checa JC

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND & AIMS:Colorectal cancers (CRC) associated with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome display high-level microsatellite instability (MSI-H) as a consequence of mismatch repair deficiency. HNPCC-associated CRC frequently show features of a pronounced immune response, most likely resul...

journal_title：Gastroenterology

authors： Schwitalle Y,Kloor M,Eiermann S,Linnebacher M,Kienle P,Knaebel HP,Tariverdian M,Benner A,von Knebel Doeberitz M

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND & AIMS:Changes in the properties of visceral sensory neurons contribute to the development of gastrointestinal pain. However, little is known about the molecules involved in mechanosensation from the gastrointestinal tract. We investigated the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK...

journal_title：Gastroenterology

authors： Sakurai J,Obata K,Ozaki N,Tokunaga A,Kobayashi K,Yamanaka H,Dai Y,Kondo T,Miyoshi K,Sugiura Y,Matsumoto T,Miwa H,Noguchi K

更新日期：2008-04-01 00:00:00

abstract：:CRC development is a multi-step process that spans 10 to 15 years, thereby providing an opportunity for early detection and even prevention. The poor survival rate of advanced CRC has prompted the emphasis on prevention of this disease. CRC screening and removal of adenomas is an effective intervention, and is the cor...

journal_title：Gastroenterology

authors： Arber N,Levin B

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND & AIMS:Celiac disease is a complex, immune-mediated disorder of the intestinal mucosa with a strong genetic component. HLA-DQ2 is the major determinant of risk, but other minor genes, still to be identified, also are involved. METHODS:We designed a strategy that combines gene expression profiling of intesti...

journal_title：Gastroenterology

authors： Castellanos-Rubio A,Martin-Pagola A,Santín I,Hualde I,Aransay AM,Castaño L,Vitoria JC,Bilbao JR

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND & AIMS:Intestinal fibrosis and stricture formation are serious complications of Crohn's disease, often requiring surgical intervention. Unfortunately, the mechanisms underlying intestinal fibrosis development are poorly understood, in part because of the lack of relevant animal models. Here, we present a nov...

journal_title：Gastroenterology

authors： Grassl GA,Valdez Y,Bergstrom KS,Vallance BA,Finlay BB

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND & AIMS:Steatosis in patients with nonalcoholic fatty liver disease (NAFLD) is due to an imbalance between intrahepatic triglyceride (IHTG) production and export. The purpose of this study was to evaluate TG metabolism in adipose tissue and liver in NAFLD. METHODS:Fatty acid, VLDL-TG, and VLDL-apolipoprotein...

journal_title：Gastroenterology

authors： Fabbrini E,Mohammed BS,Magkos F,Korenblat KM,Patterson BW,Klein S

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanisms for tissue regeneration and renewal after acute pancreatitis are not well understood but may involve activation of Notch signaling. To study the effect of Notch signaling ablation during acute experimental pancreatitis, we used a chemical and genetic approach to ablate Notch signaling i...

journal_title：Gastroenterology

authors： Siveke JT,Lubeseder-Martellato C,Lee M,Mazur PK,Nakhai H,Radtke F,Schmid RM

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND & AIMS:Triage of patients with acute upper gastrointestinal hemorrhage (UGIH) has traditionally required urgent upper endoscopy. The aim of this study is to evaluate the use of artificial neural network for nonendoscopic triage. METHODS:A cohort of 387 patients was used to train (n = 194) and internally val...

journal_title：Gastroenterology

authors： Das A,Ben-Menachem T,Farooq FT,Cooper GS,Chak A,Sivak MV Jr,Wong RC

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND & AIMS:Methionine adenosyltransferase (MAT) catalyzes S-adenosylmethionine biosynthesis. Two genes (MAT1A and MAT2A) encode for the catalytic subunit of MAT, while a third gene (MAT2beta) encodes for a regulatory subunit that modulates the activity of MAT2A-encoded isoenzyme. We uncovered multiple splicing v...

journal_title：Gastroenterology

authors： Yang H,Ara AI,Magilnick N,Xia M,Ramani K,Chen H,Lee TD,Mato JM,Lu SC

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND & AIMS:It has been proposed that activation of the sympathetic nervous system causes a rightward shift in the renal autoregulatory curve such that renal blood flow is critically dependent on renal perfusion pressure and that this contributes to the development of the hepatorenal syndrome. The aims of the stu...

journal_title：Gastroenterology

authors： Stadlbauer V,Wright GA,Banaji M,Mukhopadhya A,Mookerjee RP,Moore K,Jalan R

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND & AIMS:Long-term data on the risk of colorectal cancer according to dose, duration, and consistency of aspirin therapy are limited. METHODS:We conducted a prospective study of 47,363 male health professionals who were ages 40-75 years at enrollment in 1986. Biennially, we collected data on aspirin use, othe...

journal_title：Gastroenterology

authors： Chan AT,Giovannucci EL,Meyerhardt JA,Schernhammer ES,Wu K,Fuchs CS

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND & AIMS:Most previous population-based studies of mortality in inflammatory bowel disease (IBD) did not account for medication use. We evaluated mortality by IBD medication use among members of the Kaiser Permanente Northern California IBD Registry. METHODS:The retrospective, population-based cohort study in...

journal_title：Gastroenterology

authors： Hutfless SM,Weng X,Liu L,Allison J,Herrinton LJ

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND & AIMS:Neutrophils are generally thought to play an important proinflammatory role in the pathogenesis of inflammatory bowel disease. The objective of this study was to evaluate whether blocking the invasion of neutrophils by anti-L-selectin monoclonal antibodies modulates chemically induced colitis and how ...

journal_title：Gastroenterology

authors： Kühl AA,Kakirman H,Janotta M,Dreher S,Cremer P,Pawlowski NN,Loddenkemper C,Heimesaat MM,Grollich K,Zeitz M,Farkas S,Hoffmann JC

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND & AIMS:Epithelial stem cells in the stomach are responsible for constant renewal of the epithelium through generation of multiple gastric cell lineages that populate the gastric glands. However, gastric stem or progenitor cells have not been well-characterized because of the lack of specific markers that per...

journal_title：Gastroenterology

authors： Qiao XT,Ziel JW,McKimpson W,Madison BB,Todisco A,Merchant JL,Samuelson LC,Gumucio DL

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND & AIMS:This longitudinal study investigated the interactions and roles of hepatitis B virus (HBV) genotypes, pre-S deletions, and core promoter and precore mutations on the progression of liver disease in hepatitis B e antigen (HBeAg)-negative patients. METHODS:A total of 141 HBeAg-negative patients without...

journal_title：Gastroenterology

authors： Chen CH,Hung CH,Lee CM,Hu TH,Wang JH,Wang JC,Lu SN,Changchien CS

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND & AIMS:Entecavir demonstrated superior benefit to lamivudine at 48 weeks in nucleoside-naive patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB). We evaluated continued entecavir and lamivudine treatment through 96 weeks. METHODS:709 HBeAg-positive CHB patients were randomized to ...

journal_title：Gastroenterology

authors： Gish RG,Lok AS,Chang TT,de Man RA,Gadano A,Sollano J,Han KH,Chao YC,Lee SD,Harris M,Yang J,Colonno R,Brett-Smith H

更新日期：2007-11-01 00:00:00

abstract：:The diagnosis of inflammatory bowel disease (IBD) with its 2 main subforms, Crohn's disease and ulcerative colitis, is based on clinical, endoscopic, radiologic, and histologic criteria. This paradigm remains unchanged despite the advent of new molecular technologies for the examination of serum proteins and genetic s...

journal_title：Gastroenterology

authors： Nikolaus S,Schreiber S

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND & AIMS:Predictors of reactivation of hepatitis B following hepatitis B e antigen (HBeAg) seroconversion in chronic hepatitis B have rarely been reported before and deserve further study. METHODS:A total of 133 HBeAg-positive asymptomatic carriers who have undergone HBeAg seroconversion were studied. Reactiv...

journal_title：Gastroenterology

authors： Chu CM,Liaw YF

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND & AIMS:Because current therapies for chronic hepatitis C virus (HCV) infections are suboptimal and associated with severe side effects, novel treatment options are needed. A small animal model has recently been developed to study HCV infections. To examine the usefulness of this human liver-urokinase-type pl...

journal_title：Gastroenterology

authors： Vanwolleghem T,Meuleman P,Libbrecht L,Roskams T,De Vos R,Leroux-Roels G

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND & AIMS:This study examined the possible role of endotoxinemia (from increased gut permeability) as an additional trigger factor for overt pancreatic disease and as a promoter of chronic pancreatic injury in alcoholics by using a rat model of chronic alcohol feeding and in vitro experiments with cultured panc...

journal_title：Gastroenterology

authors： Vonlaufen A,Xu Z,Daniel B,Kumar RK,Pirola R,Wilson J,Apte MV

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatic and bile duct carcinomas represent highly aggressive malignancies that evolve from secretin receptor-rich ductular cells. With premessenger RNA splicing abnormalities common in cancer, we evaluated whether an abnormal secretin receptor spliceoform were present, characterized it, and develop...

journal_title：Gastroenterology

authors： Hayes GM,Carrigan PE,Dong M,Reubi JC,Miller LJ

更新日期：2007-09-01 00:00:00